Orexos pulverformulering öppnar för GLP-1 via näsan

Uppsalabolaget Orexo har med lovande resultat prövat sin pulverbaserade formuleringsteknologi på semaglutid – vilket kan bana väg för ett GLP-1-läkemedel som intas nasalt.

By Anders Göransson

September 5, 2025 11:30 AM

Semaglutid är den verksamma substansen i flera läkemedel från danska Novo Nordisk, bland annat Ozempic och Wegovy som gjort världssuccé som behandling mot typ 2-diabetes och fetma.

Orexo har tagit fram tre pulverbaserade intranasala semaglutidformuleringar med hjälp av sin egenutvecklade Amorphox-teknologi. Dessa jämfördes i en djurstudie med dels semaglutidtabletten Rybelsus, dels med injicerbar semaglutid i form av Wegovy.

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