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Swedish team tests Alzheimer antibody for brain imaging

Recent breakthroughs in Alzheimer’s treatment have increased the need for precise diagnostics in the field. Researchers in Uppsala are working to develop improved methods for both identifying suitable patients and ensuring they receive the right therapy.
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A research group led by Professor Dag Sehlin is developing a form of companion diagnostics, where the same antibody used to treat the disease is also employed for PET imaging of the brain for diagnostic purposes.

“There are already fairly good PET markers for amyloid-beta pathology in the brain. But the difference with our approach is that you know what you’re seeing in the brain is exactly what the therapeutic antibody binds to and neutralizes”, says Dag Sehlin.

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