Astra Zeneca går inte vidare till fas III med ny blodfettssänkare

Astra Zeneca avslutar sin utveckling av kolesterolläkemedelskandidaten ION449. Det trots att data i fas IIb-studie nådde upp till de primära effektmåtten.

By Karin Winter

September 27, 2022 8:00 AM

Läkemedelskandidaten designades av Astra Zenecas partner Ionis Pharmaceuticals, ett biotech-företag i Kalifornien, för att minska plasmanivåerna av PCSK9 hos patienter med hyperkolesterolemi. Förhoppning var att i förlängningen även minska lågdensitetslipoproteinkolesterol (LDL-C), och därmed risken för hjärt-kärlsjukdom. Kandidaten ges månadsvis som en subkutan injektion.

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